Our Science Updated


Mi·cro·bi·ome . /,mīkrō’bīōm/

A person’s microbiome is the entire collection of microbes living in and on the body. The microbiome forms a living layer over your skin and parts of the inside of your body, including the lungs and the digestive tract, from the mouth all the way down to the colon. When the microbes in your gut are out of balance, your body can't absorb nutrients the way it should. The result of this is inflammation, the root of almost every chronic disease. (Seed.com)

“All Disease Begins in The Gut.”

- Hippocrates

 

Scientific Advisors


Allison Kumar

Executive Regulatory Affairs Advisor and previously at FDA


Carolyn Splusky Ph.D.

UC Davis Food, Microbiome and Nutrition Professor


Tim Lu Ph.D. M.D.

Professor of Synthetic Biology at MIT and Co-founder of Tango Therapeutics


Mitesh Rao M.D., MHS

Chief Patient Safety Officer @ Stanford Healthcare

Our Difference: Thryve's Gut Health Kit


Indexed 36,000+ microbiome research articles

We reference most of the microbiome research articles and provide the descriptions of 3000+ kinds of bacteria in natural language. In short, we've pulled all the important information on each microbe so you get the most robust set of information on "why" each microbiome matters.

Mapped 1,000+ food ingredients

We provide diet suggestions to our customers based on their microbiome test results. Customers can discover the right foods to add or to avoid into their daily diet to enhance beneficial bacteria and reduce pathogenic bacteria.

Mapped 500+ supplements

We cite clinical and scientific studies about the benefits of supplements from relevant journals and indicate the relationship between the gut microbiome and these supplements.

Research confidence algorithm

We reference journal publications with clinical and scientific studies related to the probiotic strains and food ingredients. Our algorithm is based on consideration of the size, effects, time of the clinical studies, and impact factor of these journals.

Wellness Score algorithm

In our wellness score algorithm, we compare the amounts of probiotics, beneficial, commensal and pathogenic bacteria from our customer’s gut microbiome test to the American Gut Project results. From this comparison, we can calculate their gut microbiome diversity, which is the richness of bacterial genus or species (amounts of different bacteria) that characterizes the gut microbiome in individuals. We also consider the abundance of gut bacteria, including the percentage of beneficial bacteria (ex: Akkermansia, Bifidobacterium, Lactobacillus), proteobacteria, and more.


Highest Accuracy Testing Kit

Our testing kit uses a proprietary liquid buffer that keeps bacterial cells in stasis prior to extraction and provides 28% more accuracy in sequencing by providing more depth and species categorization. All other kits on the market use either a "dry swab" or "anti-microbials" in their liquid buffer to lyse the cells to stop them from growing during the transportation process (that's why AG has a bloom filter) and other's don't even account for this bias. What this means is that other testing companies are actually not showing you the true data of your sample!

13-1. Sample preservation buffer

Bacteria in fecal samples can grow before their genomic DNA (gDNA) gets extracted. We have developed one of the best sample preservation buffer that is able to stabilize bacteria and prevent cells from growing before they are analyzed (Figure 1). Without stabilization capability, the buffer can’t preserve bacterial composition from the initial fecal sample.

3-2. gDNA extraction

To be able to sequence gut bacteria, it is necessary to extract gDNA from them. We have developed protocols that enable us to extract bacteria evenly without bias.

3-3. Sequencing

We have implemented error correction in our pipeline and reduced the times of PCR for library preparation to lessen the possibility of PCR bias.

3-4. Bioinformatic Analysis

We have implemented error correction protocols in our bioinformatic pipeline and used the most representative database for gut microbiome.


Our Difference: Thryve's Personalized Probiotics

Clinical and scientific research for our strain formulations

Our immune health formulation contains Lactobacillus paracasei Th1 and Th2. L. paracasei Th1 is also called LP33, Th2 is called AAP-2. Several clinical studies have shown that they can modulate the immune system by alleviating symptoms of allergic rhinitis and atopic dermatitis (Ref 1, Ref 2, Ref 3). In addition, our weight management formulation contains Lactobacillus reuteri Tr1, which is also called L. ruteri ADR1. This patented probiotic strain can modulate metabolic health, help weight management (ref 4, Ref 5), and is currently under a 2017-2018 clinical trial at (Ref 6).

Our digestive health formulation contains Bacillus, Lactobacillus and Bifidobacterium species, ingredients that are derived from plants, human and dairy products. They are gluten-free and encapsulated in vegetable cellulose, which helps bypass stomach acid.

Results from our study

Validation studies with microbiome sequencing and personalized nutrition and probiotics intervention

  • Increase good bacteria

  • Decrease bad bacteria

  • Confirmed safety profile


Thryve's Academic Partnerships


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Thryve's Diet Studies

Juice Cleanse Diet

Thryve Inside recently conducted an internal study about the difference in health benefits of a juice cleanse diet vs. a regular diet of whole foods. Results found that after a three-day juice cleanse can improve intestinal health and the immune system. Let’s take a closer look at the results of our juice cleansing studies, and other juice cleanse benefits.

Whole30 Diet

Thryve Inside recently conducted an internal study about the changes in a person’s gut biome when they switched from their everyday meal plan to following Whole30 rules. Results found that after five days of going without inflammatory food groups can boost the abundance of stomach bacteria associated with weight loss. However, it does so at the determent of other stomach bacteria. What can you eat on a Whole30 diet, and is this weight loss program for you? Let’s take a closer look at our Whole30 diet study results.

McDonald's Diet

Thryve Inside recently conducted an internal study about the changes in gut bacteria when eating a diet solely comprised of McDonald’s menu items. Results found that following a three-day McDonald’s diet may decrease biodiversity in your gut. In turn, opting for Super Size and regularly have a Big Mac for a meal may impact your overall health. Let’s take a closer look at what happened when our volunteer went all Morgan Spurlock and tested out a diet strictly from McDonald’s fast food restaurants.

Keto Diet

We conducted several internal studies about which type of diet would be most conducive to optimal gut health. Switching to a ketogenic diet saw the second-highest overall increase in stomach bacteria, falling just behind a juice cleanse diet. While many of the stomach bacteria that grew were beneficial for overall health, our results didn’t point to a keto diet plan correlating with weight loss. Let’s take a look at the health benefits of a high-fat, low-carb diet and the results of our keto diet study.

  • Juice Cleanse Diet
  • Whole30 Diet
  • McDonald's Diet
  • Keto Diet
  • Soylent Diet

Thryve Inside recently conducted an internal study about the difference in health benefits of a juice cleanse diet vs. a regular diet of whole foods. Results found that after a three-day juice cleanse can improve intestinal health and the immune system. Let’s take a closer look at the results of our juice cleansing studies, and other juice cleanse benefits.

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References

1. Bousquet J, Khaltaev N, Cruz AA, Denburg J, Fokkens WJ, Togias A et al. Allergic Rhinitis and its Impact on Asthma (ARIA) 2008 update (in collaboration with the World Health Organization, GA(2)LEN and AllerGen). Allergy 2008; 63 (Suppl 86), 8–160.

2. Wang, M. F., Lin, H. C., Wang, Y. Y. and Hsu, C. H. (2004), Treatment of perennial allergic rhinitis with lactic acid bacteria. Pediatric Allergy and Immunology, 15: 152–158. doi:10.1111/j.1399-3038.2004.00156.x

3. I.-J. Wang and J.-Y. Wang, Clinical & Experimental Allergy, 2015 (45) 779–787.

4. Ting, W.-J.; Kuo, W.-W.; Hsieh, D.J.-Y.; Yeh, Y.-L.; Day, C.-H.; Chen, Y.-H.; Chen, R.-J.; Padma, V.V.; Chen, Y.-H.; Huang, C.-Y., Heat Killed Lactobacillus reuteri GMNL-263 Reduces Fibrosis Effects on the Liver and Heart in High Fat Diet-Hamsters via TGF-β Suppression. Int. J. Mol. Sci. 2015, 16, 25881-25896.

5. Lu Y-C, et al. Effect of Lactobacillus reuteri GMNL-263 treatment on renal fibrosis in diabetic rats. J Biosci Bioeng. 2010;110(6):709–715.

6. https://clinicaltrials.gov/ct2/show/NCT02274272

7. Jiang, S., Xie, S., Lv, D. et al. Antonie van Leeuwenhoek (2016) 109: 1389.

8. Patterson, Angela M. et al. “Human Gut Symbiont Roseburia Hominis Promotes and Regulates Innate Immunity.” Frontiers in Immunology 8 (2017): 1166. PMC. Web. 7 Mar. 2018.

9. https://en.wikipedia.org/wiki/Bristol_stool_scale

10. M.L. Heiman, F.L. Greenway, A healthy gastrointestinal microbiome is dependent on dietary diversity, Mol Metabol, 5 (2016), pp. 317-320

11. Zhang C, Zhang M, Pang X, Zhao Y, Wang L, Zhao L. Structural resilience of the gut microbiota in adult mice under high-fat dietary perturbations. The ISME Journal. 2012;6(10):1848-1857. doi:10.1038/ismej.2012.27.

12. Chiu C-M, Huang W-C, Weng S-L, et al. Systematic Analysis of the Association between Gut Flora and Obesity through High-Throughput Sequencing and Bioinformatics Approaches. BioMed Research International. 2014;2014:906168.